Lossless compression: When converting BAM -> CRAM -> BAM, the final BAM file will look identical to the initial BAM file. Even more about the different options on the developers homepage. There are a couple of options you can give to CRAM that will make it behave differently. We think this format will become more common, and that it will be supported by most tools, like the BAM format is today. The BAM format was a huge success due to its ability to compress aligned reads by ~50-80% of their original size, but even that is not sustainable in the long run.ĬRAM is a new program that can compress SAM/BAM files even more, which makes it suitable for long-term storage. The bioinformatics community is trying to keep up with the growing data amounts, and new file formats is part of this evolution. Biological data is being produced at a higher rate each day, and it is a challenge to store it all somewhere.
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